Anti-Ku80 Antibody (12525) (12525-100ug)

Telomere length maintenance, essential to chromosome stability and genome integrity, is regulated by telomerase and telomere-associated factors. The Ku proteins are eukaryotic nuclear proteins involved in DNA repair and telomere maintenance. They exist as a heterodimer of 70 and 80 kDa subunits (Ku 70 and Ku 80). Ku heterodimers bind to DNA ends at telomeres and at double-strand breaks where they interact with DNA-dependent protein kinase (DNA PK) and participate in targeting of DNA PK to DNA. The Ku proteins may participate in DNA repair and replication, cell signaling, proliferation, transcriptional activation, and apoptosis.