Anti-Insulin Receptor (α subunit) [Clone 18-44] (50104-100ug)

The insulin receptor (INSR) is a crucial receptor tyrosine kinase (RTK) that plays a central role in regulating glucose uptake in the body. When insulin binds to the extracellular domain of the INSR, it triggers a cascade of events leading to the absorption of glucose by cells. The INSR shares significant structural and functional similarities with the IGF-1 receptor (IGF-1R), highlighting their related roles in cellular signaling. One of the earliest cellular responses to insulin stimulation is the autophosphorylation of tyrosine residues within the INSR, a critical step in initiating the downstream signaling pathways. In humans, the gene encoding the INSR is located on chromosome 19. Dysfunctions or defects in the INSR can lead to a range of insulin resistance syndromes, impacting the body's ability to respond effectively to insulin. Similarly, defects in the IGF-1R can contribute to certain forms of growth retardation.