Anti-Human TRAIL R4 (Internal Domain)
Anti-Human TRAIL R4 (Internal Domain) (D248-GRP)
Products
Description
TNF-related apoptosis-inducing ligand receptor 4 (TRAIL R4) is a decoy receptor that negatively regulate TRAIL-induced cytotoxicity by competing for ligand binding with TRAIL-R1 and TRAIL-R2.1 TRAIL R4 is expressed mainly on CD8+ and NK cells and induces apoptosis in many tumour cells, but not in normal cells. TRAIL-R4 contains partially truncated death domain and therefore is unable to induce apoptosis and serves as a negative regulator of apoptotic signaling by impairment death-inducing signaling complex (DISC) processing.1,2
Specifications
| Manufacturer | Leinco Technologies Inc |
|---|---|
| Manufacturer Cat# | D248 |
| Concentration | 0.5 mg/ml |
| Formulation | This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative. |
| Alternate Names | Polyclonal Antibody TNF-Related Apoptosis-Inducing Ligand Receptor 4 TNFRSF10D Decoy Receptor 2 (DCR2) CD264 TRUNDD TR4 TRAIL R4 Human Anti-Human TRAIL R4 (Internal Domain) |
| Target | TNF-Related Apoptosis-Inducing Ligand Receptor 4 |
| Antibody Type | Polyclonal |
| Applications | IHC FFPE, WB |
| Storage | This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. |
| Protein | TNF-Related Apoptosis-Inducing Ligand Receptor 4 |