Anti-Human TRAIL R4 (Clone 104918)
Anti-Human TRAIL R4 (Clone 104918) (T452-GRP)
Products
Description
TNF-related apoptosis-inducing ligand receptor 4 (TRAIL R4) is a decoy receptor that negatively regulate TRAIL-induced cytotoxicity by competing for ligand binding with TRAIL-R1 and TRAIL-R2.1 TRAIL R4 is expressed mainly on CD8+ and NK cells and induces apoptosis in many tumour cells, but not in normal cells. TRAIL-R4 contains partially truncated death domain and therefore is unable to induce apoptosis and serves as a negative regulator of apoptotic signaling by impairment death-inducing signaling complex (DISC) processing.1,2
Specifications
| Manufacturer | Leinco Technologies Inc |
|---|---|
| Manufacturer Cat# | T452 |
| Formulation | This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.3 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present. |
| Alternate Names | Monoclonal Antibody TNF-Related Apoptosis-Inducing Ligand Receptor 4 TNFRSF10D Decoy Receptor 2 (DCR2) CD264 TRUNDD TR4 104918 TRAIL R4 Human Anti-Human TRAIL R4 |
| Isotype | IgG1 |
| Clone | 104918 |
| Target | TRAIL R4 |
| Antibody Type | Monoclonal |
| Applications | ELISA Cap, FC, N, WB |
| Storage | -20°C to -70°C |
| Protein | TRAIL R4 |