Anti-Human TNF-α [Clone 1825]
Anti-Human TNF-α [Clone 1825] (T427-GRP)
Products
Description
TNF-α is a 17.5 kD protein that mediates inflammation and immunity caused by the invasion of viruses, bacteria, and parasites by initiating a cascade of cytokines that increase vascular permeability, thus bringing macrophages and neutrophils to the site of infection. TNF-α secreted by the macrophage causes the blood to clot which provides containment of the infection. TNF-α binding to surface receptors brings about various biologic activities that include cytolysis and cytostasis of many tumor cell lines In vitro, hemorraghic necrosis of tumors In vivo, increased fibroblast proliferation, and enhanced chemotaxis and phagocytosis in neutrophils.
Specifications
| Manufacturer | Leinco Technologies Inc |
|---|---|
| Manufacturer Cat# | T427 |
| Formulation | This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.3 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present. |
| Alternate Names | Monoclonal Antibody Tumor Necrosis Factor Alpha TNFSF1A TNFSF2 Cachectin Differentiation-Inducing Factor [DIF] Necrosin Cytotoxin 1825 TNF-α Human Anti-Human TNF-α |
| Isotype | IgG1 |
| Clone | 1825 |
| Target | TNF-α |
| Antibody Type | Monoclonal |
| Applications | N |
| Antigen | TNF-α is secreted by macrophages, monocytes, neutrophils, T cells, B cells, NK cells, LAK cells. |
| Storage | -20°C to -70°C |
| Protein | TNF-α |