Anti-Human TIMP-1 (Clone 63515)
Anti-Human TIMP-1 (Clone 63515) (T462-GRP)
Products
Description
Tissue Inhibitor of Metalloproteinases 1, also known as TIMP1 is a widely expressed, secreted protein that functions primarily to inhibit members of a large family of metalloproteinases (MPs). Because of the ability of TIMP-1 to inhibit MPs, it functions in many of the same pathophysiological processes as these enzymes, e.g. wound healing, ovulation, angiogenesis, and cancer cell metastasis. TIMP-1 can also stimulate proliferation and cellular anabolic processes.1 TIMP-1 is a novel negative regulator of HGF activity during liver regeneration.2 Overexpression of TIMP-1 could promote renal interstitial fibrosis through the inflammatory pathway, which might be partly induced by upregulating ICAM-1.3
Specifications
| Manufacturer | Leinco Technologies Inc |
|---|---|
| Manufacturer Cat# | T462 |
| Formulation | This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.3 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present. |
| Alternate Names | Monoclonal Antibody Tissue Inhibitor of Metalloproteinases 1 EPO CLGI EPA FLJ90373 HCI TIMP 63515 TIMP-1 Human TIMP-1 Anti-Human TIMP-1 |
| Isotype | IgG2b |
| Clone | 63515 |
| Target | TIMP-1 |
| Antibody Type | Monoclonal |
| Applications | CyTOF®, ELISA Cap, FC, ICC, IHC FFPE, WB |
| Storage | -20°C to -70°C |
| Protein | TIMP-1 |