Anti-Human TIM-3 Antibody (34073) (34073-100ul)

T cell immunoglobulin and mucin domain-3 (TIM-3) is a member of the TIM gene family, which includes TIM-1, TIM-3, TIM-4 in humans and Tim-1-8 in mice. TIM-3 is expressed on Th1, Th17, and CD8+ T cells as well as on dendritic cells and natural killer cells. Binding of TIM-3 and its ligands has been found to suppress Th1 and Th17 responses and induce peripheral immune tolerance, supporting an inhibitory role of TIM-3 in T cell-mediated immune responses. TIM-3 expression also characterizes exhausted T cells during chronic infection. Since administration of TIM-3 and PD-1 mAbs synergistically control tumor growth, TIM-3 is gaining importance in tumor and chronic viral infection models as a candidate for immunotherapy in conjunction with other inhibitory receptors.