Anti-Human Tie-2 (Clone 83711)
Anti-Human Tie-2 (Clone 83711) (T433-GRP)
Products
Description
Tyrosine kinase with immunoglobulin-like and EGF-like domains 2 (Tie-2) are novel endothelial cell tyrosine kinase receptors that are essential for vascular development and remodeling in the embryo.1 They are expressed almost exclusively in endothelial cells.2 Tie-2 is functional in pericytes and may play an important role in the progression of diabetic retinopathy, by regulating pericyte loss and influencing the activation state and recruitment of pericytes.3 Tie2 has been shown to be up-regulated in psoriasis and in breast cancer tissue and blocking Tie2 action inhibits tumor angiogenesis and tumor growth.
Specifications
| Manufacturer | Leinco Technologies Inc |
|---|---|
| Manufacturer Cat# | T433 |
| Formulation | This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.3 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present. |
| Alternate Names | Monoclonal Antibody Tyrosine Kinase With Immunoglobulin And Epidermal Growth Factor Homology Domain 2 VMCM1 CD202b TEK 83711 Tie-2 Human Anti-Human Tie-2 |
| Isotype | IgG1 |
| Clone | 83711 |
| Target | Tie-2 |
| Antibody Type | Monoclonal |
| Applications | WB |
| Storage | -20°C to -70°C |
| Protein | Tie-2 |