Anti-Human TACE Ectodomain (Clone 111623)
Anti-Human TACE Ectodomain (Clone 111623) (T461-GRP)
Products
Description
TACE (tumor necrosis factor-α-converting enzyme) is a pleiotropic metalloprotease also known as ADAM17 that is found to be constitutively expressed by intestinal epithelial cells.1 TACE is a major sheddase of TNF-α and its receptors, essential for the generation of soluble, mature molecules.2 TACE as a promising target of epidermal growth factor receptor (EGFR) axis inhibition in colorectal cancer (CRC)3 and a principal target for the treatment of TNF-dependent pathologies.4
Specifications
| Manufacturer | Leinco Technologies Inc |
|---|---|
| Manufacturer Cat# | T461 |
| Formulation | This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.3 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present. |
| Alternate Names | Monoclonal Antibody Tumor Necrosis Factor-α Converting Enzyme ADAM17 CD156b MGC71942 cSVP 111623 TACE Human Anti-Human TACE Ectodomain |
| Isotype | IgG1 |
| Clone | 111623 |
| Target | TACE Ectodomain |
| Antibody Type | Monoclonal |
| Applications | IP, WB |
| Storage | -20°C to -70°C |
| Protein | TACE Ectodomain |