Anti-Human pThr474 RIPK2 Rabbit Polyclonal Antibody (19510) (19510-100ul)

RIPK2 (Receptor Interacting Protein Kinase 2) is the obligate kinase of the NOD2 intracellular pathogen recognition pathway receptor and an upstream kinase activator for NFκB via activation of TAK1. NOD2 is activated by muramyl dipeptide (MDP), a natural component of Gram-positive and Gram-negative bacteria. Upon NOD2 activation, RIPK2 is recruited to NOD and becomes activated via a tyrosine and serine phosphorylation and protein-dependent poly-ubiquitination. Active RIPK2 activates TAK1 and subsequently IKK (IκB kinases) followed by the movement of the NFκB dimer (p50 and p65) to the nucleus to turn on gene transcription. Thus, RIPK2 can play a role during inflammation injury in a number of disease settings.