Anti-Human PDGF-AA (Clone 114506)
Anti-Human PDGF-AA (Clone 114506) (P274-GRP)
Products
Description
Platelet-derived growth factor (PDGF), an agent with important mitogenic effects for bone cells, exists in three isoforms, PDGF-AA, - BB, and –AB.1 The A-chain homodimers of the platelet-derived growth factor (PDGF AA) are widely expressed in normal and transformed cells.2 PDGF AA is a potent mitogen for a wide range of cell types including fibroblast, smooth muscle, and connective tissue. PDGF-AA and its receptor represent an important epithelial-mesenchymal interaction which plays a critical role in early lung branching morphogenesis.3 PDGF AA is also an essential autocrine regulator for vascular endothelial growth factor (VEGF) expression. It regulates the frequency and level of VEGF expression during the transition from a precancerous lesion to advanced cancer.4
Specifications
| Manufacturer | Leinco Technologies Inc |
|---|---|
| Manufacturer Cat# | P274 |
| Formulation | This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.3 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present. |
| Alternate Names | Monoclonal Antibody PDGF-AA Glioma-Derived Growth Factor [GDGF] Osteosarcoma-Derived Growth Factor [ODGF] 114506 PDGF-AA Human Anti-Human PDGF-AA |
| Isotype | IgG1 |
| Clone | 114506 |
| Target | PDGF-AA |
| Antibody Type | Monoclonal |
| Applications | N |
| Storage | -20°C to -70°C |
| Protein | PDGF-AA |