Anti-Human PD-ECGF (P264-GRP)

Platelet-Derived Endothelial Cell Growth Factor (PD-ECGF) is an acidic non-glycosylated protein found in connective tissue of the placenta. It is synthesized by fibroblasts, vascular smooth muscle cells, and a number of transformed cell lines.1 PDGF promotes the proliferation and migration of pulmonary artery smooth muscle cells (PASMCs), and may play a role in the progression of pulmonary arterial hypertension (PAH), a condition characterized by proliferation of PASMCs resulting in the obstruction of small pulmonary arteries.2