Anti-Human/Mouse/Rat β-Catenin 1 (Clone 12F7) - Purified
£89.06
Anti-Human/Mouse/Rat β-Catenin 1 (Clone 12F7) - Purified (C3454-25ug)
Product
| Cat # C3454-25ug | Size 25 µg |
Price
£89.06
|
Qty
|
Description
β-catenin is an armadillo protein that binds to numerous partners, including cadherins,
adenomatosis polyposis coli, and T-cell factor 1 , and is also a principal component of the Wnt signaling pathway 2 . β-catenin is necessary for embryonic development, organ differentiation and development, bone homeostasis, mammalian hair growth, and adult tissue regeneration. Additionally, β-catenin functions in cell adhesion as part of a cadherin/catenin complex, plays an important role in the structural integrity of squamous epithelial cells 3 , and is involved in synaptic plasticity 1 . β-catenin localizes to the cell cytoplasm, and once activated, translocates to the nucleus, where it activates target genes via TCF/LEF transcription factors
Specifications
| Manufacturer | Leinco Technologies Inc |
|---|---|
| Manufacturer Cat# | C3454 |
| Product Size | 25 µg |
| Concentration | ≥1.0 mg/ml |
| Formulation | This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. |
| Clone | 12F7 |
| Target | Human/Mouse/Rat β-Catenin 1 (CTNNB1) |
| Applications | FC, IF, IHC, WB |
| Antigen | β-catenin 1 is widely expressed in many tissues, including kidney, lung, adult and developing central nervous system, several hair follicle cell types, colon, cortical neurons, and various cancers. |
| Storage | This antibody may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles. |
| Protein | Human/Mouse/Rat β-Catenin 1 (CTNNB1) |