Anti-Human/Mouse/Rat β-Catenin 1 (Clone 12F7) - Biotin
Anti-Human/Mouse/Rat β-Catenin 1 (Clone 12F7) - Biotin (C3465-GRP)
Products
Description
β-catenin is an armadillo protein that binds to numerous partners, including cadherins,
adenomatosis polyposis coli, and T-cell factor 1 , and is also a principal component of the Wnt signaling pathway 2 . β-catenin is necessary for embryonic development, organ differentiation and development, bone homeostasis, mammalian hair growth, and adult tissue regeneration. Additionally, β-catenin functions in cell adhesion as part of a cadherin/catenin complex, plays an important role in the structural integrity of squamous epithelial cells 3 , and is involved in synaptic plasticity 1 . β-catenin localizes to the cell cytoplasm, and once activated, translocates to the nucleus, where it activates target genes via TCF/LEF transcription factors
Specifications
| Manufacturer | Leinco Technologies Inc |
|---|---|
| Manufacturer Cat# | C3465 |
| Concentration | 0.5 mg/ml |
| Formulation | This Biotinylated antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative. |
| Clone | 12F7 |
| Applications | FC, IF, IHC, WB |
| Antigen | β-catenin 1 is widely expressed in many tissues, including kidney, lung, adult and developing central nervous system, several hair follicle cell types, colon, cortical neurons, and various cancers. |
| Storage | This biotinylated antibody is stable when stored at 2-8°C. Do not freeze. |
| Protein | Human/Mouse/Rat β-Catenin 1 (CTNNB1) |