Anti-Human/Mouse IL-10 (Clone JES3-9D7) - Recombinant <i>in vivo</i> functional grade (L342-GRP)

Interleukin-10 (IL-10) is a homodimeric, anti-inflammatory cytokine of 17-21 kD1. It was initially discovered because of its ability to inhibit the synthesis of various pro-inflammatory cytokines produced by T helper 1 (Th1) cells. It plays a vital role in regulating the immune response and inflammation2. IL-10 has diverse effects and can either suppress or promote immune responses based on the circumstances. Its anti-inflammatory properties include inhibiting the activity of Th1 cells, natural killer (NK) cells, and macrophages. These cells play a role in clearing pathogens but can also lead to tissue damage3-7. IL-10 supports the activation of B-cells and CD8+ T-cells and is involved in peripheral T-cell tolerance to allergens, autoantigens, transplantation antigens, and tumor antigens8. The dysregulation of IL-10 has been linked to an increased risk of autoimmune diseases and enhanced immunopathology in response to infection. In mice, the absence of IL-10 has been shown to cause inflammation and pain by COX activation, leading to dysfunctions in the vascular endothelial and cardiac systems. Studies in which IL-10 was knocked out suggest that this cytokine plays a crucial role in counteracting the hyperactive immune response in the intestinal tract. It has been reported that the treatment of Crohn’s disease patients with recombinant IL-10-producing bacteria has been beneficial. IL- 10 is associated with certain diseases such as Graft-Versus-Host Disease and Human Immunodeficiency Virus Type 19. JES3-9D7 is a monoclonal antibody that specifically targets and neutralizes human and mouse IL-10. It has been extensively studied for its ability to inhibit the biological activity of IL-10 and its potential therapeutic applications10,11.