Anti-Human/Mouse BACE-1 Ectodomain
Anti-Human/Mouse BACE-1 Ectodomain (B596-GRP)
Products
Description
BACE-1 is an aspartic protease and an integral membrane protein. BACE-1 is the peptidase predominantly responsible for cleavage of the amyloid precursor protein β site in the brain to generate the amyloid β peptide. Because the amyloid β peptide is a major component of amyloid plaques, BACE-1 has been implicated in the onset and/or progression of Alzheimer's disease. BACE-1 is expressed in a variety of human tissues. It is likely that this peptidase has functions in addition to its hydrolysis of the amyloid precursor protein. The peptidase activity of BACE-1 is optimal under mildly acidic conditions (pH 3.5 -5.5), consistent with its proposed function in an acidic intracellular compartment.
Specifications
| Manufacturer | Leinco Technologies Inc |
|---|---|
| Manufacturer Cat# | B596 |
| Formulation | This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.3 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present. |
| Alternate Names | Monoclonal Antibody Beta-Site APP Cleaving Enzyme 1 137612 BACE-1 Human Anti-Human/Mouse BACE-1 Ectodomain |
| Isotype | IgG1 |
| Clone | 137612 |
| Target | BACE-1 |
| Antibody Type | Monoclonal |
| Applications | CyTOF®, FC, IHC FFPE, WB |
| Storage | -20°C to -70°C |
| Protein | BACE-1 |