Anti-Human/Monkey CD40L (CD154) (Clone 5C8) - Biotin
Anti-Human/Monkey CD40L (CD154) (Clone 5C8) - Biotin (C587-GRP)
Products
Description
CD154, also known as CD40L, gp39, TRAP, or T BAM is a 39 kDa molecule that plays a vital role in the immune system. It belongs to the tumor necrosis factor (TNF) family and is crucial for the interaction between antigen-specific lymphocytes and antigen-presenting cells1,2. By binding to CD40 it assists in the costimulation process required for activating T cells and promoting B cell proliferation. CD40L also stimulates the secretion of immunoglobulin and facilitates Ig isotype switching when it binds to CD40 on B-cells3. Moreover, CD40L regulates cytokine production by T cells4. Due to its involvement in immune responses, this molecule is of significant importance for immunological research and therapeutic interventions5,6.
Clone 5C8 is a mouse monoclonal antibody produced through immunization of BALB/c mice with cells from a mouse myeloma cell line. It specifically recognizes human CD154 and binds to an epitope that differs from the CD40 binding site7,8.
Specifications
| Manufacturer | Leinco Technologies Inc |
|---|---|
| Manufacturer Cat# | C587 |
| Concentration | 0.5 mg/ml |
| Formulation | This Biotinylated antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative. |
| Clone | 5C8 |
| Target | CD40L |
| Applications | FA, FC, IP |
| Antigen | CD154 is primarily expressed on activated T-cells but can also be found in other cell types, including platelets, mast cells, macrophages, basophils, NK cells, B lymphocytes, smooth muscle cells, endothelial cells, and epithelial cells. |
| Storage | This biotinylated antibody is stable when stored at 2-8°C. Do not freeze. |
| Protein | CD40L |