Anti-Human Mer (M1298-GRP)

This protein is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this protein have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). [provided by RefSeq]. Recent studies has showed that the tyrosine kinase domain may be involved in hematopoiesis, embryonic development, and regulation of testicular functions.