Anti-Human IL-5 Rα - Biotin (I-764-50ug)

The functional IL-5 receptor is a heteromeric complex consisting of an alpha and beta subunit.1 The IL-5Rα chain is exclusively expressed by eosinophils, some basophils and murine B1 cells or B cell precursors.2 Like many other cytokine receptors, alternative splicing of the α-chain gene results in expression of either a membrane bound or soluble form of the α-chain. The soluble form does not lead to signal transduction and therefore has an antagonistic effect on IL-5 signaling. Both monomeric forms of IL-5Rα are low affinity receptors, while dimerization with the β-chain produces a high affinity receptor.3 In either case, the α-chain exclusively binds IL-5 and the intra-cellular portion of IL-5Rα is associated with Janus kinase (JAK) 2, a protein tyrosine-kinase essential in IL-5 signal transduction.4,5 Soluble IL-5Ralpha expression pattern in an eosinophil-associated disease such as nasal polyposis (NP).6