Anti-Human IL-17E (Clone 182203)
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Anti-Human IL-17E (Clone 182203) (I-873-500ug)
Product
Description
IL-17E, also known as IL-25, is a novel member of the IL-17 family of cytokines1 and a unique pleiotropic cytokine and may be an important mediator of inflammatory and immune responses.2 IL-17E has a heterodimeric receptor. The receptor is composed of two subunits IL-17RA and IL-17RB. Although IL-17E only binds IL-17RB directly, both subunit receptors are essential for IL-17E functions. IL-17E induces activation of NF-κB and stimulates production of the proinflammatory chemokine IL-8. 1 IL-17E may contribute to the induction and maintenance of eosinophilic inflammation in the airways by acting on lung fibroblasts and therefore has a role in asthma pathophysiology.3
Specifications
| Manufacturer | Leinco Technologies Inc |
|---|---|
| Manufacturer Cat# | I-873 |
| Product Size | 500 µg |
| Formulation | This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.3 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present. |
| Alternate Names | Monoclonal Antibody Interleukin-17E 182203 IL-17E Human Anti-Human IL-17E |
| Isotype | IgG1 |
| Clone | 182203 |
| Target | IL-17E |
| Antibody Type | Monoclonal |
| Applications | CyTOF®, FC, WB |
| Storage | -20°C to -70°C |
| Protein | IL-17E |