Anti-Human IL-1 RI (I-614-25ug)

Interleukin 1 receptor, type I (IL1R1), also known as CD121a (Cluster of Differentiation 121a, is a master regulator of inflammation and innate immunity. When triggered by IL-1beta, IL-1RI aggregates with IL-1R-associated protein (IL-1RAcP) and forms a membrane proximal signalosome that potently activates downstream signaling cascades.1 IL1R1 is expressed predominantly by T cells, fibroblasts, and endothelial cells.