Anti-Human IL-1 Receptor Associated Kinase 2 (CT-1) (IRAK-2)
£412.50
Anti-Human IL-1 Receptor Associated Kinase 2 (CT-1) (IRAK-2) (I-309-0.1mg)
Product
| Cat # I-309-0.1mg | Size 0.1 mg |
Price
£412.50
|
Qty
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Description
The pro-inflammatory cytokine IL-1 induces cellular response through two subunits of its receptor, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP). IL-1 receptor-associated kinase (IRAK) mediates activation of NF-κB , which is a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/Pelle family was recently identified and designated IRAK2.2 Both IRAK and IRAK2 recruit to the subunits of the IL-1R complex after IL-1 binding and lead to NF-κB activation. IRAKs also associate with Toll-like receptor (TLR) and the dominant negative mutants of IRAKs inhibit LPS-induced NF-κB activation.3,4 Members in IRAK/Pelle family play a central role in IL-1R and TLR mediated inflammatory responses to cytokine IL-1 and LPS. IRAK2 is expressed in a variety of human tissues.
Specifications
| Manufacturer | Leinco Technologies Inc |
|---|---|
| Manufacturer Cat# | I-309 |
| Product Size | 0.1 mg |
| Concentration | 0.5 mg/ml |
| Formulation | This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative. |
| Alternate Names | Polyclonal Antibody Interleukin-1 Receptor Associated Kinase 2 IRAK-2 Human Anti-Human IL-1 Receptor Associated Kinase 2 (CT-1) (IRAK-2) |
| Target | IRAK-2 |
| Antibody Type | Polyclonal |
| Applications | IHC FFPE, WB |
| Storage | This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. |
| Protein | IRAK-2 |