Anti-Human ICAM-1 - Purified <i>in vivo </i>GOLDâ„¢ Functional Grade
£337.50
Anti-Human ICAM-1 - Purified <i>in vivo </i>GOLDâ„¢ Functional Grade (C372-5.0mg)
Product
| Cat # C372-5.0mg | Size 5.0 mg |
Price
£337.50
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Qty
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Description
ICAM-1 is a 55 kDa glycoprotein that is part of the Ig superfamily. It is heavily glycosylated to form 75 kDa to 115 kDa. ICAM-1 is known to be an adhesion and viral entry molecule, and its long suspected involevement in signal transduction is being elucidated. The signal-transducing functions of ICAM-1 appear to be mainly associated with proinflammatory pathways. Furthermore, ICAM-1 signaling appears to act as a beacon for inflammatory immune cells such as macrophages and granulocytes bringing about inflammation via lymphocyte trafficking. ICAM-1 is essential for the transmigration of leukocytes out of blood vessels and into tissues, and is a marker of endothelial dysfunction leading to damaging vascular disorders in umbilical and placental vascular tissue of gestational pregnancies. ICAM-1 is the receptor for rhinoviruses (the cause of most common colds) and malaria, and plays an inflammatory role in ocular allergies.
Specifications
| Manufacturer | Leinco Technologies Inc |
|---|---|
| Manufacturer Cat# | C372 |
| Product Size | 5.0 mg |
| Concentration | ≥ 5.0 mg/ml |
| Formulation | This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. |
| Alternate Names | Monoclonal Antibody Inter-Cellular Adhesion Molecule 1 BB2 CD54 P3.58 15.2 ICAM-1 Human Anti-Human ICAM-1 Purified Low Endotoxin Functional Formulation |
| Isotype | IgG1 |
| Clone | 15.2 |
| Target | Inter-Cellular Adhesion Molecule 1 |
| Antibody Type | Monoclonal |
| Applications | FC, IHC FFPE, IP, WB |
| Antigen | CD54 is present on endothelial cells, lymphocytes, epithelial cells, dendritic cells and keratinocytes. |
| Storage | Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles. |
| Protein | Inter-Cellular Adhesion Molecule 1 |