Anti-Human ICAM-1 (CD54) (Clone R6-5-D6) - Recombinant <i>in vivo</i> Functional Grade (C877-GRP)

ICAM-1 or CD54 is a glycoprotein found on the surface of endothelial and epithelial cells during inflammation. It plays a significant role in the interactions between cells and immune responses. ICAM-1 helps in the adhesion and movement of leukocytes expressing activated LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18)1. Studies suggest that sICAM-1 (soluble ICAM-1) can bind to various non-integrin ligands, such as CD43/sialophorin, fibrinogen, hyaluronan, rhinoviruses, and Plasmodium falciparum-infected erythrocytes. In addition, sICAM-1 can be used as an indicator of vascular endothelial cell activation or damage by promoting angiogenesis2. Increased levels of sICAM-1 are associated with various diseases such as chronic coronary heart disease, type 2 diabetes, organ transplant dysfunction, oxidant stress, and certain malignancies3-5. Clone R6-5-D6, is a monoclonal antibody that has been used in research to study the expression and function of ICAM-1 in different contexts, such as viral infections, solid tumors, and graft-versus-host disease. The antibody has shown efficacy in inhibiting infection, characterizing ICAM-1 expression, and enhancing immune responses6-9. It also inhibits CD54 interaction with leukocytes, thereby reducing inflammation10,11.