Anti-Human FLASH (CT)
Anti-Human FLASH (CT) (F138-GRP)
Products
Description
A novel mammalian CED-4 homologous was recently identified and cloned in mouse1 and human2 and designated FLASH (for FLICE-associated huge protein). FLASH is involved in Fas induced apoptosis. It is recruited to Fas after the receptor cross-linking. Overexpression of wild type of FLASH facilitates and its dominant negative form inhibits Fas induced apoptosis. FLASH interacts with the DEDs of caspase-8 and FADD through the DED-like domain of FLASH and mediates activation of caspase-8.1 There are parallels between FLASH and Apaf-1/CED-4 although there are arguments against their structural similarity.1,2 FLASH is widely expressed.
Specifications
| Manufacturer | Leinco Technologies Inc |
|---|---|
| Manufacturer Cat# | F138 |
| Concentration | 0.5 mg/ml |
| Formulation | This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative. |
| Target | FLASH |
| Applications | IHC FFPE, WB |
| Storage | This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. |
| Protein | FLASH |