Anti-Human Eotaxin-3 (Clone 115002)
Anti-Human Eotaxin-3 (Clone 115002) (E140-GRP)
Products
Description
Eotaxin-3/CCL-26 belongs to a family of CC chemokines, which are potent chemoattractants for eosinophils that signal through the CCR3 receptor. 1 It is produced by endothelial cells stimulated with IL-4 or IL-13. Eotaxin-3 selectively targets cells expressing CCR3, including eosinophils, basophils, T cells and monocytes. It has been reported that eotaxin-3 is an antagonist for CCR2.2 Eotaxin-3 has similar activity to Eotaxin and Eotaxin-2, but the three Eotaxins share only a low degree of sequence homology. Eotaxin-3 is up-regulated in the context of a T helper 2 mediated inflammatory bowel disease via the signal transducer and activator of transcription 6, thus suggesting that the intestinal epithelium actively participates in the recruitment of eosinophils at the site of inflammation.1
Specifications
| Manufacturer | Leinco Technologies Inc |
|---|---|
| Manufacturer Cat# | E140 |
| Formulation | This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.3 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present. |
| Alternate Names | Monoclonal Antibody Eotaxin-3 SCYA26 MIP-4 Alpha Eotaxin-3 IMAC MIP-4a TSC-1 CCL26 115002 Human Anti-Human Eotaxin-3 |
| Isotype | IgG1 |
| Clone | 115002 |
| Target | Eotaxin-3 |
| Antibody Type | Monoclonal |
| Applications | ELISA Cap, N, WB |
| Storage | -20°C to -70°C |
| Protein | Eotaxin-3 |