Anti-Human Endostatin N-Terminal (a.a.1-12)
£238.13
Anti-Human Endostatin N-Terminal (a.a.1-12) (E131-0.1mg)
Product
| Cat # E131-0.1mg | Size 0.1 mg |
Price
£238.13
|
Qty
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Description
Endostatin is globular domain found at the C-terminal derived from type XVIII collagen. It serves as an anti-angiogenic agent, similar to angiostatin and thrombospondin. It is an angiogenesis inhibitor and may interfere with the pro-angiogenic action of growth factors such as basic fibroblast growth factor (bFGF/FGF-2) and vascular endothelial growth factor (VEGF). 1 On the surface of endothelial cells, endostatin binds with the integrin alpha(5)beta(1) that activates the Src-kinase pathway. The binding of endostatin with integrins also down-regulates the activity of RhoA GTPase and inhibits signaling pathways mediated by small kinases of the Ras and Raf families. All these events promote disassembly of the actin cytoskeleton, disorders in cell-matrix interactions, and decrease in endotheliocyte mobility, i.e., promote the suppression of angiogenesis. 2 Endostatin is currently being studied as part of cancer research.
Specifications
| Manufacturer | Leinco Technologies Inc |
|---|---|
| Manufacturer Cat# | E131 |
| Product Size | 0.1 mg |
| Concentration | 0.5 mg/ml |
| Formulation | This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative. |
| Alternate Names | ES Anti-Human Endostatin N-Terminal a.a.1-12 Endostatin Anti-Human Endostatin N-Terminal a.a.1-12 NE1.479 Anti-Human Endostatin N-Terminal a.a.1-12 Monoclonal Antibody Endostatin NE1.479 Human Endostatin PlGF-2 a.a.1-12 Anti-Human Endostatin N-Terminal a.a.1-12 Anti-Human Endostatin N-Terminal Anti-Human Endostatin ES Monoclonal Antibody Endostatin NE1.479 Human Endostatin PlGF2 a.a.112 AntiHuman Endostatin NTerminal a.a.112 AntiHuman Endostatin NTerminal AntiHuman Endostatin ES Monoclonal Antibody Endostatin NE1.479 Human Endostatin PlGF 2 a.a.1 12 Anti Human Endostatin N Terminal a.a.1 12 Anti Human Endostatin N Terminal Anti Human Endostatin ES Anti-Human Endostatin N-Terminal a.a.1-12 |
| Isotype | IgG1 |
| Clone | NE1.479 |
| Target | Endostatin |
| Antibody Type | Monoclonal |
| Applications | ELISA Indirect, WB |
| Storage | This purified antibody is stable when stored at 2-8°C. Do not freeze. |
| Protein | Endostatin |