Anti-Human CD8 - Purified <i>in vivo </i>GOLDâ„¢ Functional Grade
£98.44
Anti-Human CD8 - Purified <i>in vivo </i>GOLDâ„¢ Functional Grade (C366-1.0mg)
Product
| Cat # C366-1.0mg | Size 1.0 mg |
Price
£98.44
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Qty
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Description
CD8 is made up of disulfide-linked α and β chains that form the α(CD8a)/β(CD8b) heterodimer and α/α homodimer. CD8 is part of the Ig superfamily that expresses primarily as CD8a homodimers. CD8a is a 32-34 kD type I glycoprotein that can also form heterodimers with CD8b. CD8 is an antigen co-receptor on T cells that mediates efficient cell to cell interactions within the immune system. CD8 coupled with the T cell receptor on the T lymphocyte recognizes an antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The CD8 co-receptor also plays a role in T cell signaling by interacting with Lck (lymphocyte-specific protein tyrosine kinase) which leads to the activation of transcription factors that affect the expression of certain genes.
Specifications
| Manufacturer Cat# | C366 |
|---|---|
| Product Size | 1.0 mg |
| Concentration | ≥ 5.0 mg/ml |
| Formulation | This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. |
| Alternate Names | Monoclonal Antibody CD8 UCHT-4 Human CD8 Anti-Human CD8 Purified Low Endotoxin Functional Formulation Clone UCHT-4 |
| Isotype | IgG2a |
| Clone | UCHT-4 |
| Target | CD8 |
| Antibody Type | Monoclonal |
| Applications | FA, FC, in vivo, WB |
| Antigen | CD8 is expressed on blood lymphocytes, a subset of NK cells, and thymocytes. Persons with HIV exhibit increased levels of CD8+ lymphocytes. |
| Storage | Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles. |
| Protein | CD8 |