Anti-Human CD8 - FITC
Anti-Human CD8 - FITC (C119-GRP)
Products
Description
CD8 is made up of disulfide-linked α and β chains that form the α(CD8a)/β(CD8b) heterodimer and α/α homodimer. CD8 is part of the Ig superfamily that expresses primarily as CD8a homodimers. CD8a is a 32-34 kD type I glycoprotein that can also form heterodimers with CD8b. CD8 is an antigen co-receptor on T cells that mediates efficient cell to cell interactions within the immune system. CD8 coupled with the T cell receptor on the T lymphocyte recognizes an antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The CD8 co-receptor also plays a role in T cell signaling by interacting with Lck (lymphocyte-specific protein tyrosine kinase) which leads to the activation of transcription factors that affect the expression of certain genes.
Specifications
| Manufacturer Cat# | C119 |
|---|---|
| Concentration | 0.2 mg/ml |
| Formulation | This Fluorescein (FITC) conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative. |
| Alternate Names | Monoclonal Antibody CD8 UCHT-4 CD8 Human Anti-Human CD8-Fluorescein (FITC) |
| Isotype | IgG1 λ |
| Clone | UCHT-4 |
| Target | CD8 |
| Antibody Type | Monoclonal |
| Applications | FC |
| Antigen | CD8 is expressed on blood lymphocytes, a subset of NK cells, and thymocytes. Persons with HIV exhibit increased levels of CD8+ lymphocytes. |
| Storage | This Fluorescein conjugate is stable when stored at 2-8°C. Do not freeze. |
| Protein | CD8 |