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Anti-Human CD71 - Purified <i>in vivo </i>GOLDâ„¢ Functional Grade

Leinco

Anti-Human CD71 - Purified <i>in vivo </i>GOLDâ„¢ Functional Grade (C371-GRP)

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Description

CD71 is a 95 kD type II homodimeric transmembrane glycoprotein. The function of CD71 is believed to be primarily nutritional. It plays a role in the control of cellular proliferation through facilitation of iron uptake by way of ferrotransferrin binding and the recycling of apotransferrin to the cell surface. Additionally, transferrin receptor is required for erythropoiesis and proper neurological development, and it has also been suggested that a growth signal might be generated by the transferrin/transferrin receptor interaction. Current genetic analysis indicates that the structural genes for transferrin receptor and for a melanoma-associated antigen (p97), and perhaps transferrin itself, each map to a common chromosome in humans. These proteins exhibit primary sequence homology with transferrin and have the ability to bind ferric iron. Therefore, it is thought that genetic rearrangements in this iron transport region may be associated with malignant transformation. Hence, anti-CD71 mAbs are thought to have therapeutic potential in cases of human leukemia & lymphoma.

Specifications

Manufacturer Cat# C371
Concentration ≥ 5.0 mg/ml
Formulation This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added.
Alternate Names Monoclonal Antibody CD71 Transferrin Receptor T56/14 CD71 Human Anti-Human CD71 (Transferrin Receptor) Purified Low Endotoxin Functional Formulation
Isotype IgG1
Clone T56/14
Antibody Type Monoclonal
Applications FC, WB
Antigen CD71 is expressed on most proliferating cells, activated lymphocytes, monocytes, macrophages, erythroid progenitors, and brain endothelium.
Storage Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
Protein CD71