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Anti-Human CD28 - Purified <i>in vivo </i>PLATINUM™ Functional Grade

Anti-Human CD28 - Purified <i>in vivo </i>PLATINUM™ Functional Grade (C2880-GRP)

CD28 is a 44 kD glycoprotein and a member of the Ig superfamily. In its capacity as a costimulatory receptor, CD28 produces co-stimulatory signals necessary for T cell activation and survival. CD28 is the only B7 receptor constitutively expressed on naive T cells. Without having this CD28/B7 interaction, T cells will fail to respond to their specific antigen when coming in contact with an MHC/antigen complex and thus, are said to be anergic.
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Description
CD28 is a 44 kD glycoprotein and a member of the Ig superfamily. In its capacity as a costimulatory receptor, CD28 produces co-stimulatory signals necessary for T cell activation and survival. CD28 is the only B7 receptor constitutively expressed on naive T cells. Without having this CD28/B7 interaction, T cells will fail to respond to their specific antigen when coming in contact with an MHC/antigen complex and thus, are said to be anergic.
Specifications
Manufacturer Cat# C2880
Concentration ≥ 2.0 mg/ml
Formulation This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (PBS) pH 7.2 - 7.4, 150 mM NaCl with no carrier protein, potassium or preservatives added.
Alternate Names Monoclonal Antibody, CD28,MGC138290, Tp44, CD28.2, Human, Anti-Human CD28 - Purified Low Endotoxin Functional Formulation, CD28 antigen (Tp44), CD28 antigen, CD28 molecule, CD28, MGC138290, T-cell-specific surface glycoprotein CD28, Tp44, anti CD28, Cluster of Differentiation 28, MGC138290, Tp44, 37407, CD28, Human, Anti-Human CD28, anti human CD28, T44
Isotype IgG1 κ
Clone CD28.2
Applications Costim, FC, IHC FF, IP, PhenoCycler®
Antigen CD28 is expressed on thymocytes, CD4+, CD8+ peripheral T cells, NK cells.
Storage This antibody is stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.
Protein CD28