Anti-Human CD25 (IL-2Rα) – Purified
Anti-Human CD25 (IL-2Rα) – Purified (C9310-GRP)
Products
Description
CD25 (IL-2Rα) is the 55 kDa subunit of the interleukin 2 receptor alpha chain which has been shown to play roles in lymphocyte differentiation, activation, and proliferation. IL-2Rα is a transmembrane glycoprotein comprised of a heavily glycosylated extracellular domain, a transmembrane region and a short cytoplasmic tail. IL-2Rα heterodimerizes with IL-2Rβ (CD122) and IL-2Rγ (CD132) and forms the IL-2 receptor complex. IL-2Rα by itself binds IL-2 with relatively low affinity, while the IL-2 receptor complex binds IL-2 with high affinity. IL-2Rα mutations cause severe immunodeficiency.
Specifications
| Manufacturer Cat# | C9310 |
|---|---|
| Concentration | 0.5 mg/ml |
| Formulation | This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative. |
| Isotype | IgG2a |
| Clone | 7G7B6 |
| Target | CD25 |
| Applications | ELISA, FC, IF Staining, IP, WB |
| Antigen | IL-2Rα is expressed on activated mature T and B lymphocytes, during early stages of thymocytes development, pre-B cells, and in activated CD4+ memory T-lymphocytes. |
| Storage | This purified antibody is stable when stored at 2-8°C. Do not freeze. |
| Protein | CD25 |