Anti-Human CD20 - Purified
Anti-Human CD20 - Purified (C1602-GRP)
Products
Description
CD20 is a 33-37 kD transmembrane-spanning phosphoprotein that facilitates optimal B-cell immune response against T-independent antigens. It can exist in a complex with MHC class I, MHC class II, CD53, CD81, and CD82. However, CD20 can also form homo-oligomers. It has been suggested that homo-oligomerization of CD20 forms calcium ion channels in the plasma membrane of B cells. CD20 can be useful in diagnosing B-cell lymphomas and leukaemias, and is the target of mAbs in the treatment of all B cell lymphomas, leukemias, and B cell-mediated autoimmune diseases. Interestingly, studies show a link between the immune system's B cells and diabetes mellitus in which anti-CD20 antibodies rendered the T cell antibodies dysfunctional and, hence, unable to cause insulin desensitivity by a B cell antibody-modulated autoimmune response.
Specifications
| Manufacturer Cat# | C1602 |
|---|---|
| Concentration | 0.5 mg/ml |
| Formulation | This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative. |
| Alternate Names | Monoclonal Antibody Cluster of Differentiation 20 MS4A1 B1 Bp35 2H7 CD20 Human Anti-Human CD20 2h7 human 2h7 human cd20 anti cd20 anti-cd20 cd20 2h7 |
| Isotype | IgG2b κ |
| Clone | 2H7 |
| Target | CD20 |
| Antibody Type | Monoclonal |
| Applications | FC, IHC FF, IP |
| Antigen | CD20 is present on human pre B lymphocytes and on B lymphocytes, except on plasma cells, and is expressed in tandem with surface IgM. It is also expressed in some follicular dendritic cells and at low levels on a T cell subset. |
| Storage | This purified antibody is stable when stored at 2-8°C. Do not freeze. |
| Protein | CD20 |