Anti-Human CD195 (CCR5) - Purified <i>in vivo</i> GOLDâ„¢ Functional Grade
£1,710.94
Anti-Human CD195 (CCR5) - Purified <i>in vivo</i> GOLDâ„¢ Functional Grade (I-2501-50mg)
Product
| Cat # I-2501-50mg | Size 50 mg |
Price
£1,710.94
|
Qty
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Description
CCR5 antibody, HEK/1/85a/7a, recognizes C-C chemokine receptor type 5 (CCR5), also known as CD195, CC-CKR-5, CHEMR13, and HIV-1 fusion coreceptor. CCR5 is a 45 kDa seven-transmembrane G-protein-coupled receptor (GPCR). CCR5 is expressed on a subset of memory T cells, macrophages, and immature dendritic cells (DCs) and is upregulated by proinflammatory cytokines1,2. CCR5 binds to inflammatory CC-chemokines, including CCL3 (macrophage inflammatory protein (MIP)-1α), CCL4 (MIP-1β), and RANTES, which increases intracellular calcium levels and results in cytoskeletal rearrangement and chemotactic cell migration3. CCR5 is also the coreceptor for HIV-1 following binding of viral gp120 to CD44-7. The levels of CCR5 on cells influence the rate of entry of HIV-1, and patients with lower levels of CCR5 exhibit immunity against infection8. CCR5 also contributes to other human diseases, including type I diabetes9 and cancer10.
Specifications
| Manufacturer Cat# | I-2501 |
|---|---|
| Product Size | 50 mg |
| Concentration | ≥ 5.0 mg/ml |
| Formulation | This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. |
| Clone | HEK/1/85a/7a |
| Target | CD195 |
| Applications | FC, ICC |
| Antigen | CCR5 is expressed on memory T cells, macrophages, and immature dendritic cells (DCs). |
| Storage | Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles. |
| Protein | CD195 |