Anti-Human CD194 (CCR4) (Mogamulizumab) - Biotin
£297.19
Anti-Human CD194 (CCR4) (Mogamulizumab) - Biotin (LT1001-100ug)
Product
| Cat # LT1001-100ug | Size 100 µg |
Price
£297.19
|
Qty
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Description
Clone KW-0761 (Mogamulizumab) is a research-grade, humanized monoclonal antibody generated from mouse anti-CCR4 mAb7 that targets human CCR4.1 CC chemokine receptor type 4 (CCR4) is a protein that belongs to the G protein-coupled receptor family and is a receptor for a variety of CC chemokines including MCP-1, MIP-1, RANTES, TARC, and Macrophage-derived chemokine. Chemokines are involved in the development, homeostasis, and function of the immune system and are known to regulate cell trafficking of various types of leukocytes. In a 2018 Phase I clinical trial, Mogamulizumab was found to decrease the number of HTLV-1–infected cells and the levels of inflammatory markers related to HTLV-1–Associated Myelopathy.3
Specifications
| Manufacturer Cat# | LT1001 |
|---|---|
| Product Size | 100 µg |
| Concentration | 0.5 mg/ml |
| Formulation | This Biotinylated antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative. |
| Clone | KW-0761 |
| Target | CD194 |
| Applications | Depletion, ELISA, FA, FC |
| Antigen | CCR4 is primarily expressed by Th2 and regulatory T cells in addition to expression on leukemic cells in cutaneous T-cell lymphoma (CTCL). |
| Storage | Functional grade biosimilar antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles. |
| Protein | CD194 |