Anti-Human CD137 (4-1BB)
Anti-Human CD137 (4-1BB) (B591-GRP)
Products
Description
4-1BB (CD137) is a 39 kD transmembrane protein that is a member of the tumor necrosis factor (TNF) receptor family and is a co-stimulatory molecule that plays a role in T-cell-mediated proliferative response. When binding its ligand, CD137 provides costimulatory signals to both CD4 and CD8 T cells via the activation of NF-B, c-Jun and p38 downstream pathways. Crosslinking of CD137 boosts T cell proliferation, IL-2 secretion, survival and cytolytic activity. Furthermore, it can increase immune activity to eliminate tumors in mice. Agonistic anti-CD137 antibodies have been reported to stimulate a more intense immune system attack on cancers.
Specifications
| Manufacturer Cat# | B591 |
|---|---|
| Formulation | This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.3 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present. |
| Alternate Names | Monoclonal Antibody 4-1BB TNFRSF9 CD137 Antigen T-Cell Antigen ILA 145501 Human Anti-Human 4-1BB |
| Isotype | IgG2b |
| Clone | 145501 |
| Target | CD137 |
| Antibody Type | Monoclonal |
| Applications | CyTOF®, FC, WB |
| Antigen | 4-1BB is expressed on activated B cells and T cells, macrophages, and dendritic cells. |
| Storage | -20°C to -70°C |
| Protein | CD137 |