Anti-Human CD11c - Purified <i>in vivo </i>GOLDâ„¢ Functional Grade
£337.50
Anti-Human CD11c - Purified <i>in vivo </i>GOLDâ„¢ Functional Grade (C369-5.0mg)
Product
| Cat # C369-5.0mg | Size 5.0 mg |
Price
£337.50
|
Qty
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Description
LFA-1α (CD11a) and CD18 are the Integrin alpha-L and beta-2 chains respectively that combine to form LFA-1, a glycoprotein and a member of the Integrin family. Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3, ICAM4 and for F11R. LFA-1 participates in the immunological synapses between CD8+ T lymphocytes and antigen-presenting cells. The absence of LFA-1α or ß may induce LAD. The antigen contributes to natural killer cell cytotoxicity, and is involved in various immune phenomena such as leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. The CD11b/CD18 antigen is a heterodimeric surface glycoprotein on leukocytes and belongs to the ß2 integrin family. CD11b functions as a receptor for C3bi complement, clotting factor X, fibrinogen and ICAM-1. CD11c forms an α/ß heterodimeric glycoprotein (CD11c/CD18 complex) which belongs to the ß2 integrin family. The complex binds fibrinogen and reportedly serves as a receptor for iC3b and ICAM-1. During inflammatory responses, it mediates cell to cell interaction and is important in both monocyte adhesion and chemotaxis.
Specifications
| Manufacturer Cat# | C369 |
|---|---|
| Product Size | 5.0 mg |
| Concentration | ≥ 5.0 mg/ml |
| Formulation | This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. |
| Alternate Names | Monoclonal Antibody CD11c gp 150/95 3.9 CD11c Human Anti-Human CD11c (gp 150/95) Purified Low Endotoxin Functional Formulation |
| Isotype | IgG1 κ |
| Clone | 3.9 |
| Target | CD11c |
| Antibody Type | Monoclonal |
| Applications | B, CyTOF®, FA, FC, IHC FF, in vivo, WB |
| Antigen | CD11c is primarily expressed on dendritic cells, NK cells, a subset of intestinal intraepithelial lymphocytes (IEL), and some activated T cells. |
| Storage | Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles. |
| Protein | CD11c |