Anti-Human CD107a (LAMP-1) - Purified No Carrier Protein
£370.31
Anti-Human CD107a (LAMP-1) - Purified No Carrier Protein (C2521-500ug)
Product
| Cat # C2521-500ug | Size 500 µg |
Price
£370.31
|
Qty
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Description
Lysosomes are membrane-bound vacuoles that digest foreign materials and perform specialized autolysis functions1. LAMP-1 is a lysosome-associated membrane glycoprotein1 involved in lysosomal biogenesis, pH regulation, autophagy, and cholesterol homeostasis that also plays a role in natural killer (NK) cell cytotoxicity and protects NK cells from degranulation-associated damage induced by their own cytotoxic granule content2. Additionally, LAMP-1 presents carbohydrate ligands to selectins and facilitates microbial infection of Lassa virus and Mumps virus via interactions with viral glycoprotein and fusion protein F, respectively. LAMP-1 is highly abundant in lysosomes and can be used as a maker to determine the amount and distribution of lysosomes3.
H4A3 was generated by immunizing Sprague Dawley rats with NIH/3T3 cells4. Spleen cells were fused with murine myeloma P3X653-Ag8 cells. The antibody was deposited in the Developmental Studies Hybridoma Bank when first developed.
Specifications
| Manufacturer Cat# | C2521 |
|---|---|
| Product Size | 500 µg |
| Concentration | ≥1.0 mg/ml |
| Formulation | This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. |
| Clone | H4A3 |
| Target | CD107a |
| Applications | FC, IF, IHC, IP, WB |
| Antigen | LAMP-1 primarily localizes to the periphery of the lysosome and is a constituent of the lysosome membrane. LAMP1 is ubiquitously expressed in human tissues. |
| Storage | This antibody may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles. |
| Protein | CD107a |