Anti-Human CCL21 (Clone 54125)
Anti-Human CCL21 (Clone 54125) (C1407-GRP)
Products
Description
Chemokine (C-C motif) ligand 21 (CCL21) is a small cytokine belonging to the CC chemokine family. This chemokine is also known as 6Ckine (because it has six conserved cysteine residues instead of the four cysteines typical to chemokines), exodus-2, and secondary lymphoid-tissue chemokine (SLC). CCL21 elicits its effects by binding to a cell surface chemokine receptor known as CCR7. In the cancer biology CCL21 seems to have multifaceted roles. CCL21 attracts CCR7 bearing cells especially T and dendritic cells but also various cancer cells. Besides the antitumour role as leukocyte recruiting, CCL21 has been shown to facilitate dendritic cell functions and to exert an angiostatic effect. Human and mouse 6Ckine are highly conserved, exhibiting 86% amino acid sequence identity.
Specifications
| Manufacturer Cat# | C1407 |
|---|---|
| Formulation | This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.3 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present. |
| Alternate Names | Monoclonal Antibody Chemokine (C-C Motif) Ligand 21 6Ckine CKb9 ECL MGC34555 SCYA21 SLC TCA4 Exodus-2 54125 CCL21 Human Anti-Human CCL21 |
| Isotype | IgG1 |
| Clone | 54125 |
| Target | CCL21 |
| Antibody Type | Monoclonal |
| Applications | WB |
| Storage | -20°C to -70°C |
| Protein | CCL21 |