Anti-Human BAFF-R (CT)
Anti-Human BAFF-R (CT) (B514-GRP)
Products
Description
Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated BAFF, BLyS, TALL-1, THANK, and zTNF4.1-4 BAFF/BLyS was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion.1,2 Two receptors, TACI and BCMA, for BAFF were originally identified. A third receptor was identified recently and designated BAFF-R and BR3 for BLyS receptor 3. Unlike BCMA and TACI, which bind to BAFF and April, BAFF-R/BR3 is specific for BAFF and plays a predominant role in BAFF induced B cell development and survival. BAFF and its receptors are involved in B cell associated autoimmune diseases, and activate NF-kB and c-jun N-terminal kinase.4
Specifications
| Manufacturer Cat# | B514 |
|---|---|
| Concentration | 1.0 mg/ml |
| Formulation | This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative. |
| Target | B-Cell Activating Factor |
| Applications | ICC, IHC FFPE, WB |
| Storage | This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. |
| Protein | B-Cell Activating Factor |