Anti-Human Apoptosis signal-regulating kinase (NT) (ASK1)
£412.50
Anti-Human Apoptosis signal-regulating kinase (NT) (ASK1) (A251-0.1mg)
Product
| Cat # A251-0.1mg | Size 0.1 mg |
Price
£412.50
|
Qty
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Description
Mitogen-activated protein (MAP) kinase cascades are activated in response to various extracellular stimuli, including cytokines, growth factors and environmental stresses. A novel MAP kinase kinase kinase (MAPKKK) was recently identified and designated ASK1 (for apoptosis signal-regulating kinase 1) and MAPKKK5.1-3 ASK1 activated two different subgroups of MAPKK, MKK4 and MKK6, which in turn activated c-Jun N-terminal kinase (JNK) and p38 MAP kinase, respectively. ASK1/MAPKKK5 is activated by TNFR and Fas through the interaction with members of the TRAF family and Fas-associated protein Daxx. Overexpression of ASK1 induced apoptotic cell death, and a catalytically inactive form of ASK1 inhibited TNF-Α-induced apoptosis. ASK1 is expressed in variety of tissues and cell lines.
Specifications
| Manufacturer Cat# | A251 |
|---|---|
| Product Size | 0.1 mg |
| Concentration | 0.5 mg/ml |
| Formulation | This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative. |
| Alternate Names | Apoptosis signal-regulating kinase Apoptosis signalregulating kinase Apoptosis signal regulating kinase Anti-Human Apoptosis signal-regulating kinase NT ASK1 ASK1 Anti-Human Apoptosis signal-regulating kinase NT ASK1 MAPKKK MEK kinase 5 Anti-Human Apoptosis signal-regulating kinase NT ASK1 |
| Target | ASK1 |
| Antibody Type | Polyclonal |
| Applications | WB |
| Storage | This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. |
| Protein | ASK1 |