Anti-HSP-90 [Clone H90-10] (11098-200ug)

Hsp90 and Grp94: Essential Molecular Chaperones Hsp90 and the 94 kDa glucose-regulated protein (Grp94) are key molecular chaperones found in the cytosol and endoplasmic reticulum, respectively. In mammalian cells, there are at least two distinct isoforms of Hsp90, Hsp90α and Hsp90β, each encoded by a separate gene. All known members of the Hsp90 family are remarkably conserved, particularly in their N-terminal and C-terminal regions. Even without cellular stress, Hsp90 plays a critical role in essential cellular processes like hormone signaling and cell cycle control. Many important regulatory proteins, including steroid receptors, cell cycle kinases, and p53, have been identified as substrates that rely on Hsp90 for proper folding and function.