Anti-FGFR1 [Clone M5G10] (30102-250ug)

The fibroblast growth factor (FGF) family is a group of multi-functional polypeptides that function in embryonic development, tissue repair, neuronal cell survival, cardiovascular disease, and tumorigenesis. The biological activities of FGF are mediated by cell surface receptors that have tyrosine kinase activity. FGFR-1 is activated by FGF-1 and FGF-2. In neoplastic cells, overexpression of FGF-1, FGF-2 and FGF receptors appear to contribute to cellular trans- formation and proliferation. Why Choose Our Anti-FGFR1 (Clone M5G10) Antibody? Central Mediator of FGF Signaling: FGFR1 is a crucial receptor tyrosine kinase that orchestrates the diverse biological activities of the Fibroblast Growth Factor (FGF) family. These multifunctional polypeptides are vital regulators in processes ranging from early embryonic development and tissue repair to neuronal cell survival. Our M5G10 clone provides a precise probe for detecting and analyzing this pivotal receptor. Activated by Key Ligands: FGFR1 is specifically activated by its high-affinity ligands, FGF-1 and FGF-2. Understanding these interactions is fundamental to deciphering downstream signaling pathways and cellular responses. This antibody enables robust detection of FGFR1, allowing researchers to study its activation and role in various cellular contexts. Critical in Cancer Research: Dysregulation of FGFR1 signaling is frequently implicated in tumorigenesis and cancer progression. Overexpression of FGF-1, FGF-2, and various FGFR family members, including FGFR1, is known to contribute significantly to cellular transformation and uncontrolled cell proliferation in neoplastic cells. Versatile Applications for Comprehensive Analysis: Clone M5G10 is rigorously validated for use in a wide array of experimental techniques, providing researchers with flexible options for their studies