Anti-DNMT1 Antibody (12595) (12595-100ug)

DNA (cytosine-5)-methyltransferase 1 (DNMT1) is a key enzyme responsible for maintaining DNA methylation patterns, particularly during DNA replication and development. DNMT1 preferentially methylates hemimethylated DNA, ensuring the faithful transmission of epigenetic information across cell divisions. This activity is coordinated with chromatin remodeling processes, as DNMT1 interacts with histone deacetylases and other methyltransferases to regulate gene expression through both DNA and histone modifications. Disruption of normal DNMT1 function or methylation patterns has been associated with various developmental disorders and the pathogenesis of several cancers. Antibodies against DNMT1 serve as valuable tools for investigating epigenetic regulation, DNA methylation dynamics, and their implications in tumorigenesis and disease progression.