Anti-Decoy Receptor 3 (DcR3) [Clone MD3B1] - Purified (D118-100ug)

DcR3 (also known as TR6, M68, and TNFRSF6B) is a member of the tumor necrosis factor receptor superfamily1,2. DcR3 acts as a soluble decoy receptor that can modulate the effect of TNF surface receptors by competing for binding to the TNF family ligands Fas ligand, LIGHT, and TL1A. DcR3 also plays a role in the immune system by modulating T cell responses as well as differentiation and maturation of dendritic cells. Additionally, DcR3 likely plays a role in keratinocyte differentiation and egg fertilization2. DcR3 is normally expressed at very low levels but is upregulated in tumors and inflammatory tissues2. Accordingly, DcR3 is regarded as a potential biomarker for cancer metastasis and as a predictor of inflammatory disease progression. In tumors, upregulation of DcR3 prevents apoptosis and promotes growth, invasion, and angiogenesis. Additionally, upregulation of DcR3 as part of the TL1A/death receptor 3 (DR3/TNFRSF25) axis is important to the pathogenesis of various inflammatory and autoimmune diseases including silicosis, bacterial infection, coronary artery disease, inflammatory bowel disease, osteoarthritis, and rheumatoid arthritis. DcR3 can also be upregulated by ultraviolet light, epidermal growth factor, and transforming growth factor (TGF)-α.