DACH1 antibody
£210.00
DACH1 antibody (FNab02230)
Product
| Cat # FNab02230 | Size 100ug |
Price
£210.00
|
Qty
|
Description
Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter(By similarity). Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain(By similarity).
Specifications
| Manufacturer Cat# | FNab02230 |
|---|---|
| Product Size | 100ug |
| Antibody Type | Polyclonal |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| Physical Appearance | liquid |
| Purification | Immunogen affinity purified |
| Purity | ≥95% as determined by SDS-PAGE |
| Host | Rabbit |
| Isotype | IgG |
| Immunogen | dachshund homolog 1(Drosophila) |
| Alternate Names | Dachshund homolog 1 (Dach1)|DACH1|DACH |
| Calculated MW | 97-100 kDa |
| Protein ID | Q9UI36 |
| Reactivity | Human, Mouse, Rat |
| Applications | ELISA, IHC, IP, WB |
| Recommended dilution | WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200 |
| Gene ID | 1602 |