anti- DACH1 antibody

anti- DACH1 antibody

Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter(By similarity). Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain(By similarity).
Cat# Size Price Qty Buy
FNab02230 100µg £210.00

Additional Information

Property Value or Rating
Product Size 100µg
Manufacturer FineTest
Antibody Type polyclonal
Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Physical Appearance liquid
Purification Immunogen affinity purified
Purity ≥95% as determined by SDS-PAGE
Host Rabbit
Isotype IgG
Immunogen dachshund homolog 1(Drosophila)
Alternate Names DACH
Calculated MW 97-100 kDa
Protein ID Q9UI36
Reactivity Human, Mouse, Rat
Applications ELISA, IHC, IP, WB
Recommended dilution WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200
Gene ID 1602

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