Anti-CENP-A Antibody (Clone 5A7-2E11)
£328.13
Anti-CENP-A Antibody (Clone 5A7-2E11) (12597-100ug)
Product
| Cat # 12597-100ug | Size 100 µg |
Price
£328.13
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Qty
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Description
Replicated chromosomes include two kinetochores that control chromosome segregation during mitosis. Centromere Protein-A (CENP-A), a histone H3-like protein, contains a C-terminal H3-like domain which is required for centromere localization of CENP-A. It is essential for kinetochore targeting of CENP-C. In the presence of DNA, CENP-A forms an octameric complex with histones H2A, H2B, and H4. CENP-A specifically localizes to active centromeres and is a component of specialized centromeric nucleosomes on which kinetochores are assembled. CENP-A is essential for nucleosomal packaging of centromeric DNA at interphase and functions as a centromere formation marker on chromosomes.
Specifications
| Manufacturer Cat# | 12597 |
|---|---|
| Product Size | 100 µg |
| Concentration | 1.0 mg/ml |
| Formulation | Phosphate-buffered saline (PBS), pH 7.4, containing 50% glycerol and 0.09% sodium azide. |
| Clone | 5A7-2E11 |
| Target | CENP-A |
| Applications | ELISA, WB |
| Storage | This antibody is stable for at least one (1) year at -20°C. Avoid repeated freeze-thaw cycles. |