Anti-Beclin 1 Antibody (23010)
£492.19
Anti-Beclin 1 Antibody (23010) (23010-100ug)
Product
| Cat # 23010-100ug | Size 100 µg |
Price
£492.19
|
Qty
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Description
Autophagy is a catabolic process that results in the degradation of bulk cytoplasmic contents within autophagosomes and lysosomes. Beclin 1, the mammalian orthologue of yeast Atg6, has a central role in autophagy. It interacts with several cofactors (Atg14L, UVRAG, Bif-1, Rubicon, Ambra1, HMGB1, nPIST, VMP1, SLAM, IP3R, PINK and survivin) to regulate the lipid kinase Vps-34 protein and promote formation of Beclin 1-Vps34-Vps15 core complexes, thereby inducing autophagy. Beclin 1 dysfunction has been implicated in many disorders including cancer and neurodegeneration.
Specifications
| Manufacturer Cat# | 23010 |
|---|---|
| Product Size | 100 µg |
| Concentration | 1.0 mg/ml |
| Formulation | PBS, pH 7.4, 50% glycerol, 0.09% sodium azide. |
| Target | Beclin-1 |
| Applications | ICC, IF, WB |
| Storage | This antibody is stable for at least one (1) year at -20°C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles. |
| Protein | Beclin-1 |