Anti-ASIC1 Antibody (11573)
£464.06
Anti-ASIC1 Antibody (11573) (11573-100ug)
Product
| Cat # 11573-100ug | Size 100 µg |
Price
£464.06
|
Qty
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Description
Acid sensing (proton-gated) ion channel 1 (ASIC1) is a cation channel with high affinity for sodium which is gated by extracellular protons and inhibited by the diuretic amiloride. It is also permeable for Ca(2+), Li(+) and K(+) and mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. ASIC1 functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin- dependent protein kinase II phosphory- lation.
Specifications
| Manufacturer Cat# | 11573 |
|---|---|
| Product Size | 100 µg |
| Concentration | Lot Specific |
| Formulation | PBS, pH 7.4; 50% glycerol, 0.09% sodium azide. |
| Clone | S271-44 |
| Target | ASIC1 |
| Applications | ICC, IF, IHC, WB |
| Storage | This antibody is stable for at least one (1) year at -20°C. Avoid repeated freeze-thaw cycles. |
| Protein | ASIC1 |