AIM2 antibody
£210.00
AIM2 antibody (FNab00238)
Product
| Cat # FNab00238 | Size 100ug |
Price
£210.00
|
Qty
|
Description
Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8(By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.
Specifications
| Manufacturer | FineTest |
|---|---|
| Manufacturer Cat# | FNab00238 |
| Product Size | 100ug |
| Antibody Type | Polyclonal |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| Physical Appearance | liquid |
| Purification | Immunogen affinity purified |
| Purity | ≥95% as determined by SDS-PAGE |
| Host | Rabbit |
| Isotype | IgG |
| Immunogen | absent in melanoma 2 |
| Alternate Names | Interferon-inducible protein AIM2|Absent in melanoma 2|AIM2 |
| Calculated MW | 38-45 kDa |
| Protein ID | O14862 |
| Reactivity | Human, Mouse |
| Applications | ELISA, IHC, WB |
| Recommended dilution | WB: 1:500-1:5000; IHC: 1:20-200 |
| Gene ID | 9447 |